目前，關于三聯抗生素軟膏 (TAO) 和莫匹羅星預防無并發癥軟組織傷口感染的安全性和有效性的比較數據很少。本研究的目的是對這兩種制劑的相對安全性、有效性和成本效益進行一項初步研究。這是一項隨機、前瞻性、干預性研究，旨在確定在標準傷口護理和縫合后，使用 TAO 和莫匹羅星軟膏治療的受試者的無并發癥軟組織傷口感染率的差異。如果受試者符合研究納入標準，則在進入急診科時入組，并需要到急診科進行一次隨訪，以確定他們的傷口狀況（感染與未感染）。共有 99 名患者入組，并在隨訪中接受評估。兩組在傷口護理和換藥方面的自我報告依從率相似。與 TAO 組患者相比，莫匹羅星組患者的感染跡象發生率（12% vs. 6.1%）和感染發生率（4% vs. 0%）更高，盡管兩種差異均未達到統計學意義。兩組均未出現嚴重不良反應。這項初步研究發現，TAO 和莫匹羅星軟膏的傷口感染率和不良事件發生率相似。結果應在更大規模的等效性試驗中得到證實。（Am J Emerg Med 2004；22：1-3。? 2004 Elsevier Inc. 保留所有權利。）

A Prospective, Randomized Pilot Evaluation of Topical Triple Antibiotic Versus Mupirocin for the Prevention of Uncomplicated Soft Tissue Wound Infection

Little data exists comparing the safety and ef?cacy of triple antibiotic ointment (TAO) and mupirocin for prevention of uncomplicated soft tissue wound infections. The purpose of this investigation was to conduct a pilot study of the relative safety, ef?cacy, and cost effectiveness of the 2 preparations. This was a randomized, prospective, interventional study to determine the difference in infection rates of uncomplicated soft tissue wounds between subjects treated with TAO and mupirocin ointment after standard wound care and suturing. Subjects were enrolled at presentation to the ED if they met the study inclusion criteria and were required to make one follow-up visit to the ED to determine the status of their wound (infected vs. not infected). A total of 99 patients were enrolled and assessed at the follow-up visit. The groups had similar rates of self-reported compliance with wound care and dressing changes. Patients in the mupirocin group had a greater rate of signs of infection (12% vs. 6.1%), and infection (4% vs. 0%) compared with patients in the TAO group, although neither difference achieved statistical signi?cance. There were no serious adverse effects in either group. This pilot study found a similar rate of wound infection and adverse events between TAO and mupirocin ointments. Results should be con?rmed in a larger equivalency trial. (Am J Emerg Med 2004;22:1-3. ? 2004 Elsevier Inc. All rights reserved.)