一項關于多粘菌素 B 硫酸鹽-桿菌肽鋅-新霉素硫酸鹽與簡單紗布敷料在皮膚磨削傷口中的隨機研究評估了每種治療對疤痕的影響。70 名受試者的上背部有三個均勻的皮膚磨削傷口，分別用三重抗生素軟膏（多粘菌素 B-桿菌肽-新霉素）、雙重抗生素（多粘菌素 B-桿菌肽）或簡單的非封閉性紗布敷料同時治療，每天兩次，最多 14 天。在皮膚磨削后 45 天和 90 天，將皮膚表面測試部位愈合后出現的色素變化和紋理變化（疤痕）與相鄰的正常皮膚進行比較。利用熒光燈、長波紫外線和臨床彩色攝影對這些變化進行目視分級。三重抗生素軟膏在減少磨皮傷口疤痕方面優于單純使用紗布敷料。這種新軟膏的好處在對色素變化的影響方面更為明顯。（Cutis. 2000 Jun;65(6):401-4）

A Newly Formulated Topical Triple-Antibiotic Ointment Minimizes Scarring

A  randomized  study  of  polymyxin  B  sulfate-bacitracin zinc-neomycin sulfate versus simple gauzetype dressings in dermabrasion wounds assessed the  effects  that  each  treatment  had  on  scarring. Each  of  three  uniform  dermabrasion  wounds  created on the upper backs of 70 subjects was treated concurrently  with  a  triple-antibiotic  ointment (polymyxin  B-bacitracin-neomycin),  a  double  antibiotic (polymyxin B-bacitracin), or a simple, non-occlusive, gauze-type dressing, twice daily for up to  14  days.    Pigmentary  changes  and  textural changes  (scarring)  appearing  after  healing  at  the skin surface test sites were compared to adjacent normal skin at 45 and 90 days post-dermabrasion. These changes were graded visually utilizing fluorescent  light,  long-wave  ultraviolet  light,  and  by clinical  color  photography.    The  triple-antibiotic ointment was superior to simple gauze-type dressing  alone  in  minimizing  the  scarring  observed  in dermabrasion  wounds.    The  benefit  of  this  new ointment was more pronounced in its effect on pigmentary changes. （Cutis. 2000 Jun;65(6):401-4）