本研究旨在比較外用藥物對上海某醫院患者分離出的痤瘡丙酸桿菌的抗菌活性。根據臨床和實驗室標準研究所確定培養的痤瘡丙酸桿菌的最低抑菌濃度。比較了性別、年齡、病程、既往治療和疾病嚴重程度對克林霉素和紅霉素的敏感性。從 98 名患者（70.41%）中分離出 69 株痤瘡丙酸桿菌菌株。對三聯抗生素軟膏（新霉素/桿菌肽/多粘菌素 B）和桿菌肽的敏感性為 100%。對夫西地酸的敏感性為 92.7%。對硫酸新霉素、紅霉素和克林霉素的耐藥率分別為 11.7%、49.3% 和 33.4%?？肆置顾睾图t霉素的高耐藥率與性別、既往治療及病情嚴重程度相關，與年齡及病程無關；局部用藥不宜單獨長期治療，以免產生多重耐藥，局部用藥應由臨床醫生根據臨床情況決定。

Antimicrobial activity of topical agents against Propionibacterium acnes: an in vitro study of clinical isolates    

This study aimed to compare the antimicrobial activities of topical agents against Propionibacterium acnes isolated from patients admitted to a hospital in Shanghai, China. The minimal inhibitory concentrations of the cultured P. acnes were determined in accordance with the Clinical and Laboratory Standards Institute. Susceptibilities to clindamycin and erythromycin were compared in terms of gender, age, disease duration, previous treatment, and disease severity. A total of 69 P. acnes strains were isolated from 98 patients (70.41%). The susceptibility to triple antibiotic ointment (neomycin/bacitracin/polymyxin B) and bacitracin was 100%. The susceptibility to fusidic acid was 92.7%. The resistance rates to neomycin sulfate, erythromycin, and clindamycin were 11.7%, 49.3%, and 33.4%, respectively. The high resistance rate to clindamycin and erythromycin was significantly affected by gender, previous treatment, and disease severity rather than by age and disease duration. Topical antibiotics should not be used separately for long-term therapy to avoid multiresistance. The use of topical antibiotics should be determined by clinicians on the basis of clinical conditions.

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Antimicrobial activity of topical agents.pdf